GHRP2- An oral Growth Hormone Releasing Peptide to battle sarcopenia (muscle wastage)
Ghrelin is a relatively well-known hormone that can significantly influence the release of growth hormone (GH) from the pituitary gland, unfortunately Ghrelin has also been dubbed ‘the hunger hormone’ since its use can trigger hunger pangs.
However, there is now an analogue of Ghrelin called GHRP2 (growth hormone releasing peptide 2) that still stimulates the production of GH, but without any significant side-effects of causing the desire to eat.
The growth hormone releasing peptides (including sermorelin) have been advocated by research physicians such as Richard Walker, M.D., Ph.D., since they offer a number of advantages over injecting GH itself, these advantages are:
- GHRPs lack a negative feedback loop, which means that it is difficult to down-regulate one’s natural GH production by using it. This represents a significant safety factor.
- GHRPs can be stored at room temperature and do not require refrigeration.
- GHRP2 can be used orally, (unlike GH itself which is only effective via subcutaneous injection).
- Injecting GH creates a bolus large square wave release of GH into the bloodstream, this is not bioidentical. However using GHRPs creates amplification of the natural (and throughout the day) production of GH, thereby enhancing rather than ‘forcing’ GH into the bloodstream.
GHRP2 has been studied* in 94 volunteers aged between 40 and 70 years. Over a period of 90-days the subjects consumed 10 ml of GHRP2 by mouth in the morning. Their average IGF-1 levels (a measure of GH in the blood) was 103.54ng/ml and rose to an average of 120.47ng/ml by the end of the period.
Other measures taken before-and-after included total body fat which decreased, on average, by 9.14% with visceral fat levels decreasing, on average, by 14.27% (with no significant changes in the placebo group). At the same time, muscle mass (as lean body mass) increased on average by 5.37% in the GHRP2 group; plus, forced lung capacity was increased on average by 16.61% (and again there no significant changes in the placebo group). Remember these effects were seen when GHRP2 was taken by mouth- not by injection.
At the same time, improvements were also noted to the patients waist and hips and ratios, total body composition (fat, water, bone and muscle mass), and forced lung capacity.
All these positive changes to these aging biomarkers corroborate findings from the studies that utilized GH injections. Therefore it is proof that GHRPs offer a real world alternative to GH injections.
Dr. Walker has gone on record to state that Sermorelin taken at bedtime (which enhances the release of GH into the bloodstream) and GHRP2 taken first thing AM (which increases production of GH), when combined can offer a 5-fold efficacy. Therefore these two agents (used sublingually and orally respectively) can be considered to be extremely synergistic.
Few side effects have been noted in the studies, some experience soft stools and upset stomachs. There have also been increases in the total blood platelet count, but values have remained within the normal clinical range.
The toxicity and LD50 ratios for GHRP2 also look good and therefore when used within its normal clinical dose ranges should not present any problems.
Naturally it would be prudent to monitor blood GH levels (actually measured via IGF-1), to ensure that they stay within the normal ‘youthful’ level.
GHRP2 can be taken up to 10 ml first thing in the morning. These dose levels can be advocated when the patient needs to significantly raise their GH levels to achieve results, (as achieved in the study mentioned above). However, once levels and results are confirmed, the daily maintenance dose is recommended at 4 ml daily.
*A phase III, randomized, open label, placebo controlled clinical study to evaluate the efficacy and safety of GHRP2 for the treatment of age related changes in form, function and quality of life in healthy subjects. Date on file, ProSoma FLA, 2 March, 2012.
Frequently Asked Questions About GHRP 2
Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical / published results.
“What is the difference between GHRP2 and GHRP6? When should I use one over the other?”
“Both are derivatives of Ghrelin, but we have noted that GHRP2 appears to have less hunger feelings after use than GHRP6. As such, we feel that GHRP2 may be better suited to people who want to lose weight and GHRP6 may be better suited to those who want to increase their muscle mass- which by definition means increasing body weight.”
“How many milligrams are there in each 120 ml bottle?”
“Each bottle has 120 mg in it, so each ml is 1 mg.”