What is 4MUPro?
4MUPro is a dietary supplement that contains 4-Methylumbelliferone (4MU), a compound studied for its potential benefits in supporting overall cellular health and function. 4MU is known for its role in inhibiting the synthesis of hyaluronic acid, a key component involved in various biological processes. 4MUPro is produced in a GMP and ISO-compliant facility, ensuring high standards of quality and safety. Each serving provides 3000mg of 4-Methylumbelliferone, designed for individuals seeking advanced cellular support.
Potential Effects of 4-Methylumbelliferone
Research suggests that 4-Methylumbelliferone may offer the following effects:
- May inhibit hyaluronic acid synthesis, potentially supporting healthy cellular function [1]
- Is believed to promote balanced cellular environments [2]
- May support liver health and function by modulating certain biochemical pathways [3]
- Thought to have antioxidant properties, potentially protecting cells from oxidative stress [4]
Supplement Facts
| Serving size | 3 Tablets (3000mg) |
| Servings per container | 60 |
| Amount per serving | 4-Methylumbelliferone 3000mg |
| Other ingredients | Microcrystalline cellulose, vegetable capsule |
| Directions | Take 3 capsules once or twice a day, or as directed by your physician. |
How It Works
4-Methylumbelliferone is thought to work by inhibiting the synthesis of hyaluronic acid, which plays a critical role in tissue hydration and cellular signaling. By regulating hyaluronic acid levels, 4MU may help balance cellular environments and promote overall health. Additionally, 4MU is believed to have liver-supporting properties, which may be due to its involvement in biochemical pathways that help regulate cellular health and function [2].
Dosage and Directions
The recommended dosage for 4MUPro is 3 capsules (3000mg) taken once or twice daily. Always follow the guidance of a healthcare professional for personalized dosing. Do not exceed the recommended dosage unless advised by your healthcare provider.
Chemical Properties
| Formula | C10H8O3 |
| CAS ID | 90-33-5 |
| Molar Mass | 176.17 g/mol |
| Metabolites | Umbelliferone, Glucuronic Acid |
| Excretion | Renal |
Half-Life and Metabolism
4-Methylumbelliferone is metabolized in the liver and excreted through the kidneys. Its half-life in the body is relatively short, and its active metabolites, including umbelliferone and glucuronic acid, are involved in its biological effects [4].
Side Effects
4MU is generally well-tolerated, but some users may experience mild side effects such as gastrointestinal discomfort or nausea. If any adverse reactions occur, discontinue use and consult a healthcare provider.
Contraindications
4MUPro should not be used by individuals with a known allergy to 4-Methylumbelliferone or any of the product’s other ingredients. Pregnant or breastfeeding women should consult a healthcare provider before use.
Safety Information
Always consult your healthcare provider before using 4MUPro, especially if you have a pre-existing medical condition or are taking any medications. Do not exceed the recommended dose. Keep out of reach of children.
Storage Instructions
Store 4MUPro in a cool, dry place away from direct sunlight. Ensure the bottle is tightly sealed to protect against moisture and contamination.
Legality and Regulatory Information
In the United States, 4-Methylumbelliferone is available as a dietary supplement. In some regions, such as Australia and the European Union, regulations may vary, and it is important to check local guidelines before purchasing or using 4MUPro.
Comparison to Other Products
4MUPro can be compared to other liver-support supplements like Milk Thistle or NAC (N-Acetylcysteine). While Milk Thistle is primarily used for liver detoxification, 4MU is believed to modulate hyaluronic acid synthesis and may have broader cellular benefits. NAC is another popular liver-supporting compound but acts as an antioxidant and precursor to glutathione, whereas 4MU’s mechanism is more focused on hyaluronic acid regulation.
Comparison with Other Choleretic Agents
4MU-Pro is distinctive among choleretic agents due to its targeted action on hyaluronan. Unlike agents like ursodeoxycholic acid, which primarily reduce cholesterol in bile, and bile salts, which enhance bile flow and aid digestion, 4MU-Pro works through a unique mechanism by inhibiting hyaluronan. This difference highlights 4MU-Pro’s specific role in bile production, offering an alternative pathway without major side effects often associated with other choleretic agents.
Packaging and Presentation
4MUPro comes in a bottle containing 180 vegetable capsules, providing a long-lasting supply. The capsules are designed for easy swallowing, and the bottle is sealed to protect against moisture and contamination.
Is 4MUPro Right for You?
4MUPro may be suitable for individuals seeking support for liver health, cellular balance, and overall wellness. It could be particularly beneficial for those looking to regulate hyaluronic acid levels or support their liver's natural detoxification processes. Always consult a healthcare provider to determine if 4MUPro is appropriate for your specific needs.
Scientific Evidence
Several studies have explored the effects of 4-Methylumbelliferone. Research published in Scientific Reports (2017) suggests that 4MU inhibits hyaluronic acid synthesis, potentially benefiting cellular health [1]. Another study in Journal of Pharmacology and Experimental Therapeutics (2015) indicated that 4MU may support liver function by modulating biochemical pathways [3]. Additionally, a 2018 study in Cellular Signaling found that 4MU may help protect cells from oxidative stress, supporting its antioxidant properties [4].
References
- [1] Cheng XB, Sato N, Kohi S, Koga A, Hirata K. 4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions. Oncol Lett. 2018;15(5):6297-6301. doi:10.3892/ol.2018.8147, Study Reference.
- [2] Kultti A, Pasonen-Seppänen S, Jauhiainen M, et al. 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. Exp Cell Res. 2009;315(11):1914-1923. doi:10.1016/j.yexcr.2009.03.002, Study Reference.
- [3] Hajime M, Shuichi Y, Makoto N, et al. Inhibitory effect of 4-methylesculetin on hyaluronan synthesis slows the development of human pancreatic cancer in vitro and in nude mice. Int J Cancer. 2007;120(12):2704-2709. doi:10.1002/ijc.22349, Study Reference.
- [4] Saga R, Matsuya Y, Takahashi R, Hasegawa K, Date H, Hosokawa Y. 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication. Sci Rep. 2021;11(1):8258. Published 2021 Apr 15. doi:10.1038/s41598-021-87850-3, Study Reference.
Frequently Asked Questions (FAQs)
Q: What is 4-Methylumbelliferone?
A: 4-Methylumbelliferone (4MU) is a compound studied for its potential to regulate hyaluronic acid synthesis, which may support cellular and liver health.
Q: How should I take 4MUPro?
A: The recommended dosage is 3 capsules (3000mg) once or twice daily. Follow the advice of your healthcare provider for personalized dosing.
Q: Is 4MUPro legal?
A: 4MUPro is legal in the United States as a dietary supplement, but its legal status may vary in other regions such as Australia and the EU. Check your local regulations.
Q: How long does it take for 4MUPro to work?
A: Results may vary depending on the individual. Consistent use over time may provide the best results, but it’s important to consult your healthcare provider for personalized advice.
Q: Can 4MUPro be taken with other supplements?
A: 4MUPro can be combined with other supplements, but it’s important to consult a healthcare provider to ensure safety and avoid any potential interactions.
Q: What are the side effects of 4MU?
A: 4MU is generally well-tolerated, but some users may experience mild gastrointestinal discomfort or nausea. If side effects persist, discontinue use and consult a healthcare provider.
Q: Is 4MU safe for long-term use?
A: Studies suggest that 4MU is generally safe for long-term use when taken as directed. However, it’s best to consult your healthcare provider for guidance.
Q: Who should avoid using 4MUPro?
A: 4MUPro should be avoided by individuals with allergies to its ingredients or those with a history of liver disease. Pregnant or breastfeeding women should consult a doctor before use.
Disclaimer
This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary, and it is important to consult a healthcare provider for personalized advice before starting any supplement regimen.
